#4 – Four Ways to Treat DI

Please enter The Classroom.

classroom-lowresPublic involvement is needed to save lives after head injury.

Chances are that a teen was involved in a car accident, resulting in a head injury. Even as a teen in school, you may be the first to notice changes in your BFF. Your Best Friend Forever will thank you for saving her life.

After a head injury, the pituitary gland can malfunction due to physical damage that disrupts nerve cells, neurons. While the brain cells have something called neuroplasticity to re-learn how to act together in a bundle, someone can die of kidney failure before the neurons heal. This is because the body simple urinates itself into kidney failure and death.

So watch for BIG THIRST = BIG PEE in someone after a head injury, as you could literally save his or her life.

You could even ask the doctor, “Do you think she could have DI?”


The treatment of diabetes insipidus, or DI, after a head injury is very serious. One can have complications for any and all kinds of reasons, having to do with the drug treatment. There is no way of getting around this problem, so be aware of the serious nature of the prescription drugs, no matter which one you take.

Be sure to talk to your pharmacist before taking the drug, and call your doctor, nurse, and/or pharmacist for assistance in getting your drug regimen ‘right’ for you.

Don’t run out of this medication! It may have to be specially-ordered from your pharmacist, so ask for the refill before you need it. Do not let your bottle get empty unless you have a back-up. Since it needs to be refrigerated, pack it in a cool pack for travel.

Four Ways to Treat DI:

AKA The 4 Forms of Vasopressin, or DDAVP, or Desmopressin:


  1. Nasal spray. This is great if you can’t swallow pills or need an easy route of administration.

But I found this to be difficult to dose, as each spray needs to be exact. You have to hold the bottle just right and squeeze the same squirt out every time.

2. Pills. These are easy to take, as they are quite small. The dose is the exact same amount, and it can last overnight. I found these best to take before bedtime so I didn’t have to wake up to pee.

3. Injection. Like the insulin of diabetes mellitus, the injectable DDAVP can be self-treated. Make a bubble under the skin, like a mosquito or bee sting (I found that many doctors and nurses wanted to incorrectly inject it into the muscle). Remember that the skin has poor absorption, in general, so that if your skin is cold, the drug won’d absorb well. You may get the right, exact dose into the right skin area, but your metabolism of the skin may cause it to have different effects on your body.

4. Film. A film on or under the tongue can melt in your mouth. It was not available at the time of my DI, so I do not have any personal experience with it. Please let us know if you use it, and how you like it.

The good news is that for most people, the pituitary gland heals on its own, in time.

Both of my episodes spontaneously resolved, and I am free of this disease.

Persevere through this challenging time, as you will be okay!

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Thank you for reading my writings.

There is more on this subject in my new book, The Rebel Patient, Coming Soon!

Join “The MD, PhD Is In” mdphdisin-on-twitter

The Collection: Brain Injury

#1 – Ten Signs of a Brain Injury

#2 – Five Tests to Diagnose a Brain Injury

#3 – Sweet Urine and DI

#4 – Four Ways to Treat DI

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Additional Articles by Dr. Margaret Aranda

Organic Orange Blueberry Scones

Organic Blueberry Buttermilk Muffins

Organic Paleo Muffins

Organic Carrot Cake

Diabetes & Obesity

How are you Aging?

10 Complications of Diabetes

10 Health Benefits of the Low-Glycemic Diet

Chronic Metabolic Syndrome is Killing US

What does ‘Iatrogenic’ Mean?

What is a Diagnosis?

7 Ways that Chronic Pain Changes the Brain

What Matters to You: Patient Advocacy

From Dr. Forrest Tennant: Hyperalgesia: No Reason to Stop or Reduce Opioids

~ ~ ~

Read Dr Margaret Aranda’s Memoirs:

Age 1: A Baby in the Sky for Father’s Day

Age 2: The Making of a Woman Intensivist

Age 3: In the Blink of a Car

Age 4: Respond, Don’t React

Age 5: A Baby on the Edge

Age 6: Glistening in the Moonlight

Age 7: The Pigeon Boy, The Suction Bush and The Darkness

Age 8: Selling Cupcakes

Age 9: Sitting on the Edge of a Cave

Age 10: Mr Bubble Strikes Again

~ ~ ~

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